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Popularized by the Huberman podcast, but the evidence is almost nonexistent. One rat study showed testosterone increases -- along with concerning testicular toxicity markers. The risk/reward is terrible.
Fadogia Agrestis receives one of the lowest scores in our database because the risk/reward profile is among the worst available. The evidence is limited to rat studies that showed both testosterone increases AND concerning toxicity markers. The 12-point hype penalty reflects the massive gap between podcast-driven popularity and scientific evidence. Taking a compound with known animal toxicity signals and zero human safety data is not evidence-based supplementation -- it is experimentation.
Fadogia Agrestis has been catapulted to popularity primarily through the Huberman Lab podcast. The entire evidence base consists of a handful of animal studies in rats. A 2005 Nigerian study in rats showed increased testosterone levels but also noted dose-dependent testicular toxicity markers and increased testicular weight -- which could indicate pathological changes. There are zero published human clinical trials. The mechanism of action is not established. No long-term safety data exists in any species at commonly marketed doses.
| Ingredient | Dose | Verdict |
|---|---|---|
| Fadogia Agrestis Stem Extract | 600mg | Unknown |
Why the true cost is higher
This product has 0 underdosed and 1 unknown-dose ingredients. To actually get clinically effective doses, you would need approximately 3 servings per day -- making your real cost $1.29 per effective dose instead of the listed $0.43.
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Zero human clinical trials. Rat studies showed concerning testicular toxicity markers. No established safety profile at any dose in humans. Popularity driven entirely by a single podcast, not by research. Most products lack standardization -- you may not be getting what the label claims. This is one of the highest-risk supplements in our database.
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