Loading
Loading
Standalone apigenin at the commonly recommended 50mg dose. Apigenin is a flavonoid found in chamomile that acts as a mild GABA-A receptor modulator. Jarrow Formulas provides this in a clean capsule at a competitive price, though the evidence base for isolated apigenin supplementation is still developing.
Jarrow Apigenin scores 72 as a solid standalone option for those building a sleep stack. The evidence score reflects that while apigenin's mechanism is well-understood (GABA-A modulation), human clinical trials with isolated apigenin are limited — most evidence comes from chamomile extract studies where apigenin is one of several bioactives. Zero hype penalty because Jarrow is a science-focused brand that does not overclaim. The value is good at $0.20/capsule for a relatively niche ingredient.
Apigenin is a flavonoid and the primary bioactive in chamomile. Salehi et al. (2019, Molecules) extensively reviewed apigenin's pharmacology, confirming it acts as a positive allosteric modulator at GABA-A receptors — the same target as benzodiazepines, but with a much weaker binding affinity that reduces abuse potential. Viola et al. (1995, Planta Medica) identified apigenin as the compound responsible for chamomile's anxiolytic effects in animal models. Campbell et al. (2021) found 50mg apigenin improved sleep quality scores, though the study was small and industry-funded. Amsterdam et al. (2009, Journal of Clinical Psychopharmacology) showed chamomile extract (containing apigenin) reduced anxiety in patients with generalized anxiety disorder. The evidence specifically for isolated apigenin at 50mg in humans is still limited — most research uses chamomile extracts containing multiple bioactives.
| Ingredient | Dose | Verdict |
|---|---|---|
| Apigenin (from chamomile extract) | 50mg | Adequate |
Save $3.00/month (50%)
by switching to Natrol Melatonin 1mg
The human evidence for isolated apigenin at 50mg is still developing — most clinical trials used chamomile extract, not pure apigenin. It is unclear whether 50mg is the optimal dose, as dose-response studies in humans are lacking. Apigenin may inhibit CYP1A2 and CYP3A4 enzymes, potentially interacting with medications metabolized by these pathways. Not suitable as a standalone sleep solution — works best combined with magnesium and L-theanine. The GABA-A modulation is mild — do not expect benzodiazepine-level effects.
Biorank may earn a commission from qualifying purchases. This does not influence our scores or rankings.
Better-rated options in Sleep
Popular picks in Sleep