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Biorank Laboratories
NAD+ Optimization
Educational purposes only. Not medical advice. Always consult your doctor before starting supplements.
Maximizing nicotinamide adenine dinucleotide levels for cellular energy production, DNA repair, sirtuin activation, and epigenetic maintenance
Alysa Analysis for
NAD+ Optimization
Priority Guide
The most direct NAD+ precursor. Bypasses the rate-limiting NAMPT enzyme step. Human RCTs confirm it raises blood NAD+ levels within 2 weeks. Yoshino et al. showed improved muscle insulin sensitivity in prediabetic women.
Recommended Dose
500mg daily sublingual or enteric-coated (morning, empty stomach)
Expected Timeframe
2-4 weeks for NAD+ elevation; 8-12 weeks for functional benefits
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Activates SIRT1 — the NAD+-dependent deacetylase that mimics caloric restriction. Without adequate NAD+, SIRT1 cannot function regardless of resveratrol dose. Synergistic with NMN: NMN provides the fuel, resveratrol presses the accelerator.
Recommended Dose
500-1000mg trans-resveratrol daily with a fat source (yogurt, olive oil, nuts)
Expected Timeframe
4-8 weeks
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Emerging CD38 inhibitor — CD38 is the enzyme primarily responsible for NAD+ degradation. CD38 increases with age and inflammation, making it a major driver of NAD+ decline. By blocking CD38, apigenin preserves existing NAD+ stores.
Recommended Dose
50mg daily
Expected Timeframe
4-8 weeks (supports NMN efficacy)
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Methyl donor that prevents methyl group depletion from NMN metabolism. NMN-to-NAD+ conversion consumes methyl groups. Without TMG, long-term NMN use may deplete SAMe and impair methylation — a critical epigenetic process.
Recommended Dose
500-1000mg daily (take with NMN)
Expected Timeframe
Ongoing (supportive cofactor)
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
Always consult your doctor or qualified healthcare provider before starting any supplement regimen, especially if you have existing health conditions or take medications.
Supplements may interact with medications and are not intended to diagnose, treat, cure, or prevent any disease.
The evidence ratings reflect our analysis of published research and may not capture every nuance of individual health situations.