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Supplements marketed for hormonal support, PMS, and menopause. The evidence is thin for most, but we score what exists honestly.
The most studied herbal supplement for PMS and cycle regulation. Vitex agnus-castus has moderate evidence for reducing PMS symptoms (breast tenderness, mood, bloating) and may help with luteal phase defects. The evidence is better than most hormonal supplements but still limited by small study sizes.
DIM (from cruciferous vegetables) is marketed as an estrogen modulator, but the clinical evidence is extremely preliminary. Most data comes from in-vitro studies and small pilot trials. The 'estrogen detox' and 'hormone balancing' claims vastly overstate the current science.
Widely used for PMS and menopause symptoms but clinical evidence is disappointing. Systematic reviews find no significant benefit over placebo for cyclical breast pain or PMS. The GLA (gamma-linolenic acid) mechanism is biologically plausible but the clinical data does not support the traditional use.