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Ultra-cheap ferrous sulfate at therapeutic doses. Effective for iron repletion but the ferrous sulfate form causes significantly more GI side effects (constipation, nausea, cramping). USP-verified. Best for those who tolerate ferrous sulfate well and want maximum value.
Nature Made Iron earns credit for incredible value ($0.04/serving), USP verification, and therapeutic dosing. The formulation score is low because ferrous sulfate is the least tolerated iron form -- not because it does not work, but because so many people cannot stay on it. No hype penalty -- this is a straightforward generic iron product. If you tolerate it, it is the cheapest effective iron option.
Ferrous sulfate is the most studied iron form with decades of clinical data confirming efficacy for iron deficiency anemia treatment. The 65mg elemental iron dose (from 325mg ferrous sulfate) provides a therapeutic repletion dose. However, ferrous sulfate has well-documented GI side effects that cause 30-50% of patients to discontinue treatment. The poor tolerability is the primary limitation. USP verification ensures label accuracy. Nature Made uses the standard pharmaceutical form.
| Ingredient | Dose | Verdict |
|---|---|---|
| Iron (Ferrous Sulfate) | 65mg elemental | Optimal |
Ferrous sulfate causes significant GI side effects in 30-50% of users. Must be taken on an empty stomach for best absorption (which worsens nausea). 65mg is a high dose that increases side effect risk. The tablet form dissolves in the stomach rather than intestine, contributing to GI irritation.
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