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The only magnesium form shown to cross the blood-brain barrier effectively. Strong evidence for cognitive function and sleep. Premium pricing reflects patented form.
Life Extension's Magtein earns high marks for using the patented, research-backed form at the studied dose (2000mg Magtein providing 144mg elemental magnesium). The cognitive-specific evidence is unique to this form. Minor hype penalty for the growing 'nootropic' marketing angle that sometimes overstates the current evidence base. Transparency and manufacturing quality are excellent.
Magnesium L-Threonate (Magtein) is the only form of magnesium demonstrated in peer-reviewed research to significantly increase brain magnesium levels. A 2010 MIT study showed it enhanced learning, working memory, and synaptic plasticity in animal models. Human trials indicate improvements in cognitive function, particularly in older adults, and subjective sleep quality. The evidence base is growing but still limited compared to general magnesium supplementation research.
| Ingredient | Dose | Verdict |
|---|---|---|
| Magnesium L-Threonate (Magtein) | 2000mg (144mg elemental Mg) | Optimal |
Save $22.50/month (75%)
by switching to NOW Foods Magnesium Glycinate
Provides only 144mg elemental magnesium per day -- not sufficient as a sole magnesium supplement if addressing deficiency. The cost per mg of elemental magnesium is significantly higher than other forms. Evidence base, while promising, is still smaller than for magnesium glycinate or citrate. Three capsules per day is less convenient than single-dose alternatives.
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