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Fisetin is a flavonoid found in strawberries and apples that has emerged as a potent senolytic compound in preclinical research — meaning it selectively kills senescent ('zombie') cells. Yousefzadeh et al. (2018) showed fisetin was the most potent senolytic among 10 flavonoids tested in mice. However, no human clinical trial results for fisetin as a senolytic have been published yet.
ProHealth Fisetin scores 62 as an 'Evidence Weak' product — not because the science is uninteresting, but because the human evidence simply does not exist yet. The mouse data is genuinely exciting (Yousefzadeh et al., 2018), and the Mayo Clinic is running trials, but no human results have been published. Scoring higher would require actual human clinical trial data. No hype penalty because ProHealth does not overclaim, and the senolytic field is legitimately promising — it just is not proven in humans yet.
Yousefzadeh et al. (2018, EBioMedicine) screened 10 flavonoids and found fisetin was the most potent senolytic in human cell culture and mouse models, reducing senescent cell burden and extending median and maximum lifespan in aged mice. The Mayo Clinic launched the AFFIRM trial (NCT03675724) to test fisetin in elderly adults, but results have not been published. Zhu et al. (2017, Aging Cell) established the conceptual framework for senolytics — drugs that selectively kill senescent cells. Fisetin's senolytic activity is attributed to inhibition of pro-survival pathways (PI3K/AKT, HIF-1α) in senescent cells. The human bioavailability of fisetin is unknown. The leap from mouse senolytic data to human longevity claims is enormous and unvalidated.
| Ingredient | Dose | Verdict |
|---|---|---|
| Fisetin (from Rhus Succedanea) | 500mg | Unknown |
Why the true cost is higher
This product has 0 underdosed and 1 unknown-dose ingredients. To actually get clinically effective doses, you would need approximately 3 servings per day -- making your real cost $1.74 per effective dose instead of the listed $0.58.
Save $47.70/month (91%)
by switching to NOW Foods Quercetin 500mg
Zero published human clinical trial data for fisetin as a senolytic. Human bioavailability of fisetin is unknown and may be poor (like many flavonoids). The optimal human dose for senolytic effects is not established — 500mg/day is a guess extrapolated from animal data. Intermittent high-dose 'senolytic pulses' may be more effective than daily dosing (based on senolytic theory) but ProHealth is marketed for daily use. The Mayo Clinic AFFIRM trial results would be transformative for this category but remain unpublished.
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