Loading
Loading
NAD+ precursors, senolytics, mitochondrial support, and cellular repair compounds. We separate the proven from the hyped in the fastest-growing supplement category.
A well-formulated CoQ10 supplement using the ubiquinol form with BioPerine for enhanced absorption. CoQ10 is one of the better-evidenced supplements for mitochondrial support, with decades of research in cardiovascular health and cellular energy production. Doctor's Best delivers 200mg at an excellent price point.
Jarrow's ubiquinol CoQ10 uses Kaneka's patented QH form — the same reduced form of CoQ10 your body actually uses. Kaneka is the world's largest CoQ10 manufacturer and holds the original ubiquinol patent. A premium CoQ10 at a fair price from a well-regarded supplement brand.
Sulforaphane is the most potent natural activator of the Nrf2 pathway — the master regulator of cellular antioxidant defenses. Avmacol provides broccoli sprout extract with myrosinase enzyme to ensure glucoraphanin converts to active sulforaphane in the gut. Decades of research link sulforaphane to cancer chemoprevention, detoxification enhancement, and anti-inflammatory effects.
The most clinically studied NAD+ precursor supplement on the market. ChromaDex's patented Niagen (nicotinamide riboside) has been used in multiple published human trials. 300mg per capsule, FDA safety-notified, and backed by more human data than any competing NAD+ booster.
Quercetin is a widely available flavonoid with anti-inflammatory, antioxidant, and emerging senolytic properties. NOW Foods delivers 500mg at an exceptional price ($0.15/serving). While quercetin alone is a weaker senolytic than dasatinib+quercetin combinations used in research, it has broader evidence for anti-inflammatory effects, immune support, and cardiovascular health.
A high-dose NMN (nicotinamide mononucleotide) supplement from a longevity-focused brand. 500mg per capsule with third-party testing. NMN is a direct NAD+ precursor that showed impressive results in animal studies, and early human trials are encouraging but not yet definitive.
Life Extension's NAD+ formula uses nicotinamide riboside (Niagen) as the active ingredient. A well-established supplement brand with decades of history, offering NR at a reasonable price point. Life Extension has a reputation for science-driven formulation, though their product naming can be more marketing-forward than the evidence warrants.
A sublingual NMN tablet designed to bypass first-pass liver metabolism for potentially better bioavailability. Renue By Science (formerly Alive By Science) is a longevity-focused brand that has invested in liposomal and sublingual delivery systems. The sublingual approach is scientifically reasonable but unproven to be superior in human trials.
A UK-based longevity brand offering NMN at a more competitive price point than US alternatives. DoNotAge positions itself as a science-first company and provides third-party testing, though it is a newer brand with less track record than established players.
Mitopure is a patented form of urolithin A, a postbiotic compound that activates mitophagy (the recycling of damaged mitochondria). Timeline is a Swiss biotech spin-off from EPFL with legitimate research credentials. The science is emerging but intriguing — urolithin A is one of the more novel approaches in the longevity space.
A 12-ingredient longevity stack that tries to hit every hallmark of aging in one product. Novos positions itself as the 'all-in-one longevity supplement' with ingredients targeting NAD+, senescence, mitochondrial function, epigenetic aging, and more. Ambitious in scope but thin on evidence for the specific combination and doses used.
Spermidine is a naturally occurring polyamine that induces autophagy — the cellular self-cleaning process. Oxford Healthspan's Primeadine is a wheat germ-derived spermidine supplement positioned as a longevity essential. Epidemiological data links dietary spermidine to reduced mortality, but supplementation trials are very limited.
Fisetin is a flavonoid found in strawberries and apples that has emerged as a potent senolytic compound in preclinical research — meaning it selectively kills senescent ('zombie') cells. Yousefzadeh et al. (2018) showed fisetin was the most potent senolytic among 10 flavonoids tested in mice. However, no human clinical trial results for fisetin as a senolytic have been published yet.
Alpha-ketoglutarate (AKG) is a Krebs cycle intermediate that has shown lifespan extension in mice and emerged as a longevity supplement candidate. Ames et al. (2021) showed calcium AKG extended healthspan and compressed morbidity in mice. In humans, a small study suggested AKG supplementation might reduce biological age markers. Double Wood offers AKG at an excellent price, but the human evidence is still very early.
Resveratrol was once the darling of the anti-aging world, propelled by David Sinclair's high-profile research on sirtuins and red wine compounds. Life Extension's formulation combines trans-resveratrol with quercetin and other polyphenols. The reality: resveratrol has poor bioavailability in humans, the Sinclair-linked company (Sirtris) was acquired by GSK for $720M and then shuttered, and human clinical trials have been largely disappointing.